igg rabbit cst  (Cell Signaling Technology Inc)

Journal: The Journal of Pharmacology and Experimental Therapeutics

Article Title: Modeling Corticosteroid Pharmacokinetics and Pharmacodynamics, Part II: Sex Differences in Methylprednisolone Pharmacokinetics and Corticosterone Suppression

doi: 10.1124/jpet.119.257527

Figure Lengend Snippet: PD parameter estimates for plasma CST suppression by MPL

Article Snippet: This is in close agreement with a previously reported value (25 minutes) based on the elimination kinetics of CST after a 5 mg/kg IV bolus ( Sainio et al., 1988 ). table ft1 table-wrap mode="anchored" t5 TABLE 3 caption a7 Parameter Definition Estimate (% CV) Circadian Rhythm Parameters for CST T (h) Biorhythmic period 24 a , b , c a 0 Fourier coefficient 115.7 a , b /254.4 b a 1 −120.9 a , b /−168.7 b a 2 38.8 a , b /56.9 b b 1 −41.1 a , b /−95.6 b b 2 1.6 a , b /29.1 b Pharmacodynamic Parameters k deg,CST (h −1 ) Loss rate constant for CST 1.38 (12.6) a , b , c τ (h) Time to CST stress 0.34 (12.8) a , b , c CST stress (ng/ml) Maximal CST due to stress 535 (18.0) a /1292 (13.3) b /1397 (12.9) c IC 50,CST (ng/ml) Half-maximal inhibition concentration 3.4 (47.6) a /41.6 (48.0) b /12.9 (45.6) c Open in a separate window a Male. b Estrus female. c Proestrus female.

Techniques: Inhibition, Concentration Assay